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Advantages and limitations of various in silico, in vivo, in vitro or microfluidics models of BBB in the context of anticancer drug development.

Journal: Translational Oncology

Article Title: Bioengineered microfluidic blood-brain barrier models in oncology research

doi: 10.1016/j.tranon.2021.101087

Figure Lengend Snippet: Advantages and limitations of various in silico, in vivo, in vitro or microfluidics models of BBB in the context of anticancer drug development.

Article Snippet: For example, commercially available SynVivo BBB microfluidic chip can be used for the development of such platforms without much facilities and expertise for microfluidic devise development [ , ].

Techniques: In Silico, In Vivo, In Vitro, High Throughput Screening Assay, Permeability, PAMPA Assay, Isolation, Binding Assay, Migration

Various types of microfluidic BBB models, their advantages, disadvantages and applications.

Journal: Translational Oncology

Article Title: Bioengineered microfluidic blood-brain barrier models in oncology research

doi: 10.1016/j.tranon.2021.101087

Figure Lengend Snippet: Various types of microfluidic BBB models, their advantages, disadvantages and applications.

Article Snippet: For example, commercially available SynVivo BBB microfluidic chip can be used for the development of such platforms without much facilities and expertise for microfluidic devise development [ , ].

Techniques: Permeability, Adsorption, Expressing